Known in ancient times as Antioch on the Orontes,  Ἀντιόχεια ἡ ἐπὶ Ὀρόντου

Antioch was founded by Seleucus I Nicator (one of Alexander’s successor generals) after the coalition of Seleucus I (ruler of Babylonia), Lysimachus (ruler of Thrace) and Cassander (of Macedon) had won the Battle of Ipsus in 301 B.C. defeating Antigonus I Monophthalmus “one-eyed” (ruler of Phrygia), and his son Demetrius I (of Macedon) and taking the whole of Syria. Seleucus I named the city after his father Antiochus. Seleucus I Tetradrachm
Seleucus I portrait on Antiochus I tetradrachm.
Image thank you Classical Numismatic Group, Inc.,

In Seleucid times the mint at Antioch began to take over from the capital mint at Seleucia On the Tigris.

Roman Antioch with its port Seleucia Pieria was always a significant trading hub of the Empire.

The offices of the City mint issued coins by special decree of the Senate. S-C Senatus Consultum.

Byzantine mint at Antioch

Anitoch was badly damaged in the earthquake of 526. This was followed by a Sasanid sacking in 540 and the relocation of the captive and traumatized population. Justinian I makes an attempt at a revival but Antioch declines, passing between Byzantine and Sasanid empires.

later… Crusader mint at Antioch

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